Can sin against God bring a permanent curse?
Yes. Living a life of sin will bring the curse of God upon oneself. To be cursed by the Creator of the universe is the worse thing that could ever happen to someone. Only a fool would seek to bring the curse God upon himself. The curse of God upon the unsaved is not just in this life but also in the hereafter. Those who reject Jesus Christ, the Son of God suffer the curse of God through all eternity! That horrifying curse is punishment in the Lake of Fire! And that curse and punishment never ends! It goes on forever and ever and ever and ever! There is no end to that curse!
"Jesus said to him, "I am the way, the truth, and the life. No one comes to the Father except through Me" (John 14:6).